- Centre de Compétence
Maladies rares de l’hypophyse
- CHU LILLE
- Hôpital Claude Huriez
Les Missions du centre
- Assurer une expertise diagnostique
- Favoriser les actions de prise en charge et proposer un parcours de soins adapté pour les patients et leurs familles
La liste des pathologies concernées par le centre
- Adénomes hypophysaires
- Acromégalie, Maladie de Cushing
- Insuffisances hypophysaires acquises et congénitales
- Déficits en hormone de croissance
- Diabète insipide
- Hypophysites
- Craniopharyngiome et autres tumeurs de la région hypophysaire
- Hypogonadismes hypogonadotrophiques (déficits gonadotropes)
- Séquelles hypophysaires de la radiothérapie
- Syndrome de McCune-Albright
- Pubertés précoces centrales
Consultations
- Prise de rendez-vous :
consult.endodiabnut@chru-lille.fr :
Votre nom, prénom et date de naissance;
Le courrier du médecin adresseur (médecin traitant ou spécialiste);
Le dernier bilan sanguin;
Tous examens complémentaires utiles au rendez-vous.
- Lieu : Hôpital Huriez, 4ème étage aile Ouest, rue Michel Polonovski 59000 Lille
Hôpital Huriez du CHU de Lille – rue Polonowski à Lille (chu-lille.fr)
- Dr Christine CORTET médecin référent du centre
- Pr. Marie Christine VANTYGHEM médecin endocrinologue
- Dr Emilie MERLEN médecin endocrinologue
- Dr Gustavo SOTO-ARES neuroradiologue
- Dr Sabine DEFOORT-DHELLEMMES, Dr Vasily SMINOV neuro-ophtamologiste
- Pr Richard ASSAKER neurochirurgien
- Pr RHEINS gammaknife
- Dr Christine LEFEVRE endocrino-pédiatre
- Evaluation des thérapeutiques innovantes en pathologie hypophysaire
- Prise en charge des tumeurs agressives
- Pathologies hypophysaires syndromiques
- Interventions dans des sessions de FMC, l’enseignement des DES au niveau régional et national
- Interventions dans des congrès nationaux ou internationaux
- Interventions dans le DU des pathologies hypophysaires
1: Illouz F, Chanson P, Sonnet E, Brue T, Ferriere A, Raffin Sanson ML,
Vantyghem MC, Raverot G, Munier M, Rodien P, Briet C. Somatostatin receptor
ligands induce TSH deficiency in thyrotropin-secreting pituitary adenoma. Eur J
Endocrinol. 2021 Jan;184(1):1-8. doi: 10.1530/EJE-20-0484. PMID: 33112257.
2: Chevalier B, Odou MF, Demonchy J, Cardot-Bauters C, Vantyghem MC. Multiple
Endocrine Neoplasia Type 4: Novel CDNK1B variant and immune anomalies. Ann
Endocrinol (Paris). 2020 Jun;81(2-3):124-125. doi: 10.1016/j.ando.2020.04.002.
Epub 2020 Apr 10. PMID: 32386678.
3: Fleseriu M, Petersenn S, Biller BMK, Kadioglu P, De Block C, T’Sjoen G,
Vantyghem MC, Tauchmanova L, Wojna J, Roughton M, Lacroix A, Newell-Price J.
Long-term efficacy and safety of once-monthly pasireotide in Cushing’s disease:
A Phase III extension study. Clin Endocrinol (Oxf). 2019 Dec;91(6):776-785. doi:
10.1111/cen.14081. Epub 2019 Oct 1. PMID: 31465533; PMCID: PMC6899900.
4: Lacroix A, Gu F, Gallardo W, Pivonello R, Yu Y, Witek P, Boscaro M, Salvatori
R, Yamada M, Tauchmanova L, Roughton M, Ravichandran S, Petersenn S, Biller BMK,
Newell-Price J; Pasireotide G2304 Study Group. Efficacy and safety of once-
monthly pasireotide in Cushing’s disease: a 12 month clinical trial. Lancet
Diabetes Endocrinol. 2018 Jan;6(1):17-26. doi: 10.1016/S2213-8587(17)30326-1.
Epub 2017 Oct 12. Erratum in: Lancet Diabetes Endocrinol. 2018 Jan;6(1):e1.
PMID: 29032078.
5: Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S;
French Endocrinology Society non-functioning pituitary adenoma work-group.
Management of clinically non-functioning pituitary adenoma. Ann Endocrinol
(Paris). 2015 Jul;76(3):239-47. doi: 10.1016/j.ando.2015.04.002. Epub 2015 Jun
- PMID: 26072284.
6: Galland F, Vantyghem MC, Cazabat L, Boulin A, Cotton F, Bonneville JF,
Jouanneau E, Vidal-Trécan G, Chanson P. Management of nonfunctioning pituitary
incidentaloma. Ann Endocrinol (Paris). 2015 Jul;76(3):191-200. doi:
10.1016/j.ando.2015.04.004. Epub 2015 Jun 6. PMID: 26054868.
7: Nozières C, Zhang CX, Buffet A, Dupasquier S, Vargas-Poussou R, Guillaud-
Bataille M, Cordier-Bussat M, Ruszniewski P, Christin-Maitre S, Murat A,
Groussin L, Vezzosi D, Cardot-Bauters C, Hervieu V, Joly MO, Giraud S, Odou MF,
Gimenez-Roqueplo AP, Goudet P, Borson-Chazot F, Calender A; Groupe français des
tumeurs endocrines (GTE). p.Ala541Thr variant of MEN1 gene: a non deleterious
polymorphism or a pathogenic mutation? Ann Endocrinol (Paris). 2014
Jul;75(3):133-40. doi: 10.1016/j.ando.2014.05.003. Epub 2014 Jul 2. PMID:
24997771.
8: Castinetti F, Guignat L, Giraud P, Muller M, Kamenicky P, Drui D, Caron P,
Luca F, Donadille B, Vantyghem MC, Bihan H, Delemer B, Raverot G, Motte E,
Philippon M, Morange I, Conte-Devolx B, Quinquis L, Martinie M, Vezzosi D, Le
Bras M, Baudry C, Christin-Maitre S, Goichot B, Chanson P, Young J, Chabre O,
Tabarin A, Bertherat J, Brue T. Ketoconazole in Cushing’s disease: is it worth a
try? J Clin Endocrinol Metab. 2014 May;99(5):1623-30. doi: 10.1210/jc.2013-3628.
Epub 2014 Jan 28. PMID: 24471573.
9: Leroy C, Karrouz W, Douillard C, Do Cao C, Cortet C, Wémeau JL, Vantyghem MC.
Diabetes insipidus. Ann Endocrinol (Paris). 2013 Dec;74(5-6):496-507. doi:
10.1016/j.ando.2013.10.002. Epub 2013 Nov 25. PMID: 24286605.
10: Vantyghem MC, Balavoine AS, Wémeau JL, Douillard C. Hyponatremia and
antidiuresis syndrome. Ann Endocrinol (Paris). 2011 Dec;72(6):500-12. doi:
10.1016/j.ando.2011.10.001. Epub 2011 Nov 25. PMID: 22119069.
11: Mouton F, Faivre-Defrance F, Cortet-Rudelli C, Assaker R, Soto-Ares G,
Defoort-Dhellemmes S, Blond S, Wemeau JL, Vantyghem MC. TSH-secreting adenoma
improved with cabergoline. Ann Endocrinol (Paris). 2008 Jun;69(3):244-8. doi:
10.1016/j.ando.2008.02.001. Epub 2008 May 19. PMID: 18486933.
12: Vantyghem MC, Douillard C, Evrard A, Lefebvre J. Relations entre l’axe
corticotrope et l’arginine vasopressine en pathologie endocrinienne
[Relationship between corticotropin and arginine vasopressin in endocrine
diseases]. Presse Med. 1999 Jun 5;28(20):1085-90. French. PMID: 10394380.
13: Evrard A, Hober C, Racadot A, Lefebvre J, Vantyghem MC. Hormone
natriurétique auriculaire et fonctions endocrines [Atrial natriuretic hormone
and endocrine functions]. Ann Biol Clin (Paris). 1999 Mar-Apr;57(2):149-55.
French. PMID: 10210741.
14: Vantyghem MC, Cortet C, Bauters C, Gevaert MH, Dewailly D, Lefebvre J,
Mazzucca M. Immunohistochemical detection of glycoprotein hormone alpha subunit
in somatoprolactinic and pure somatotroph adenomas. J Endocrinol Invest. 1998
Jul-Aug;21(7):434-40. doi: 10.1007/BF03347322. PMID: 9766257.
15: Giraud S, Zhang CX, Serova-Sinilnikova O, Wautot V, Salandre J, Buisson N,
Waterlot C, Bauters C, Porchet N, Aubert JP, Emy P, Cadiot G, Delemer B, Chabre
O, Niccoli P, Leprat F, Duron F, Emperauger B, Cougard P, Goudet P, Sarfati E,
Riou JP, Guichard S, Rodier M, Meyrier A, Caron P, Vantyghem MC, Assayag M, Peix
JL, Pugeat M, Rohmer V, Vallotton M, Lenoir G, Gaudray P, Proye C, Conte-Devolx
B, Chanson P, Shugart YY, Goldgar D, Murat A, Calender A. Germ-line mutation
analysis in patients with multiple endocrine neoplasia type 1 and related
disorders. Am J Hum Genet. 1998 Aug;63(2):455-67. doi: 10.1086/301953. PMID:
9683585; PMCID: PMC1377295.
16: Cortet-Rudelli C, Coche-Dequeant B, Castelain B, Blond S, Hamon M, Defoort
S, Vantyghem MC, Fossati P, Dewailly D. Radiothérapie hypophysaire. Données
actuelles et perspectives d’avenir [Pituitary radiotherapy. Current data and
future prospects]. Ann Endocrinol (Paris). 1997;58(1):21-9. French. PMID:
9207963.
17: Vantyghem MC, Hober C, Lefebvre J. Diabètes insipides congénitaux.
Acquisitions récentes en génétique moléculaire [Congenital diabetes insipidus.
Recent advances in molecular genetics]. Presse Med. 1996 Feb 24;25(7):299-303.
French. PMID: 8685170.
18: Decanter C, Hober C, Hamon M, Lafitte JJ, Lefebvre J, Vantyghem MC. Diabète
insipide révélateur d’une métastase hypophysaire d’un carcinome bronchique
[Diabetes insipidus revealing pituitary metastasis of bronchial carcinoma]. Ann
Endocrinol (Paris). 1996;57(5):411-7. French. PMID: 8991105.
19: Evrard A, Vantyghem MC, Huglo D, Hober C, Marchandise X, Mazzuca M, Lefebvre
- Adénome gonadotrope fixant un analogue de la somatostatine marquée. Absence
de corrélation avec l’efficacité thérapeutique [Gonadotropi adenoma linking
labeled somatostatin analogs. Lack of relationship with therapeutic effect]. Ann
Endocrinol (Paris). 1996;57(3):209-14. French. PMID: 8949416.
20: Prévost G, Vantyghem MC, Hober C, Evrard A, Huglo D, Bonneville L, Epelbaum
J, Lefebvre J. Les adénomes thyréotropes: revue de la littérature. A propos de
deux cas [Thyreotropic adenoma: review of the literature. Apropos of 2 cases].
Ann Endocrinol (Paris). 1996;57(3):194-202. French. PMID: 8949414.
21: Le Tourneau T, Tison E, Auffray JL, Hachulla E, Vantyghem MC, Millaire A,
Ducloux G. Syndrome de sécrétion inappropriée d’ADH et hyperéosinophilie au
cours d’une maladie de Horton avec sténoses des artères sous-clavières
[Inappropriate ADH secretion syndrome and hypereosinophilia in Horton disease
with stenosis of the subclavian arteries]. Rev Med Interne. 1994
Apr;15(4):273-8. French. doi: 10.1016/s0248-8663(94)80032-4. PMID: 8059148.
- Lasolle H, Elsensohn MH, Wierinckx A, Alix E, Bonnefille C, Vasiljevic A,
Cortet C, Decoudier B, Sturm N, Gaillard S, Ferrière A, Roy P, Jouanneau E,
Bertolino P, Bardel C, Sanlaville D, Raverot G. Chromosomal instability in the
prediction of pituitary neuroendocrine tumors prognosis. Acta Neuropathol
Commun. 2020 Nov 10;8(1):190. doi: 10.1186/s40478-020-01067-5. PMID: 33168091;
PMCID: PMC7653703.
23: Duhamel C, Ilie MD, Salle H, Nassouri AS, Gaillard S, Deluche E, Assaker R,
Mortier L, Cortet C, Raverot G. Immunotherapy in Corticotroph and Lactotroph
Aggressive Tumors and Carcinomas: Two Case Reports and a Review of the
Literature. J Pers Med. 2020 Aug 13;10(3):88. doi: 10.3390/jpm10030088. PMID:
32823651; PMCID: PMC7563495.
24: Allard L, Albarel F, Bertherat J, Caron PJ, Cortet C, Courtillot C, Delemer
B, Jublanc C, Maiter D, Nunes ML, Raverot G, Sarfati J, Salenave S, Corruble E,
Choucha W, Chanson P. Efficacy and safety of dopamine agonists in patients
treated with antipsychotics and presenting a macroprolactinoma. Eur J
Endocrinol. 2020 Aug 1;183(2):221-231. doi: 10.1530/EJE-20-0125. PMID: 32583656.
25: Castinetti F, Albarel F, Archambeaud F, Bertherat J, Bouillet B, Buffier P,
Briet C, Cariou B, Caron P, Chabre O, Chanson P, Cortet C, Do Cao C, Drui D,
Haissaguerre M, Hescot S, Illouz F, Kuhn E, Lahlou N, Merlen E, Raverot V, Smati
S, Verges B, Borson-Chazot F. French Endocrine Society Guidance on endocrine
side effects of immunotherapy. Endocr Relat Cancer. 2019 Feb;26(2):G1-G18. doi:
10.1530/ERC-18-0320. PMID: 30400055; PMCID: PMC6347286.
26: Briet C, Albarel F, Kuhn E, Merlen E, Chanson P, Cortet C. Expert opinion on
pituitary complications in immunotherapy. Ann Endocrinol (Paris). 2018
Oct;79(5):562-568. doi: 10.1016/j.ando.2018.07.008. Epub 2018 Jul 25. PMID:
30126625.
27: Castinetti F, Albarel F, Archambeaud F, Bertherat J, Bouillet B, Buffier P,
Briet C, Cariou B, Caron P, Chabre O, Chanson P, Cortet C, Do Cao C, Drui D,
Haissaguerre M, Hescot S, Illouz F, Kuhn E, Lahlou N, Merlen E, Raverot V, Smati
S, Verges B, Borson-Chazot F. Endocrine side-effects of new anticancer
therapies: Overall monitoring and conclusions. Ann Endocrinol (Paris). 2018
Oct;79(5):591-595. doi: 10.1016/j.ando.2018.07.005. Epub 2018 Jul 11. PMID:
30056975.
28: Young J, Bertherat J, Vantyghem MC, Chabre O, Senoussi S, Chadarevian R,
Castinetti F; Compassionalte use Programme. Hepatic safety of ketoconazole in
Cushing’s syndrome: results of a Compassionate Use Programme in France. Eur J
Endocrinol. 2018 May;178(5):447-458. doi: 10.1530/EJE-17-0886. Epub 2018 Feb 22.
PMID: 29472378.
29: Reznik Y, Barat P, Bertherat J, Bouvattier C, Castinetti F, Chabre O, Chanson
P, Cortet C, Delemer B, Goichot B, Gruson D, Guignat L, Proust-Lemoine E, Sanson
MR, Reynaud R, Boustani DS, Simon D, Tabarin A, Zenaty D. SFE/SFEDP adrenal
insufficiency French consensus: Introduction and handbook. Ann Endocrinol
(Paris). 2018 Feb;79(1):1-22. doi: 10.1016/j.ando.2017.12.001. Epub 2018 Jan 12.
PMID: 29338844.
30: McCormack A, Dekkers OM, Petersenn S, Popovic V, Trouillas J, Raverot G,
Burman P; ESE survey collaborators. Treatment of aggressive pituitary tumours
and carcinomas: results of a European Society of Endocrinology (ESE) survey
- Eur J Endocrinol. 2018 Mar;178(3):265-276. doi: 10.1530/EJE-17-0933. Epub
2018 Jan 12. PMID: 29330228.
31: Cortet C, Barat P, Zenaty D, Guignat L, Chanson P. Group 5: Acute adrenal
insufficiency in adults and pediatric patients. Ann Endocrinol (Paris). 2017
Dec;78(6):535-543. doi: 10.1016/j.ando.2017.10.008. Epub 2017 Nov 23. PMID:
29174201.
32: Lasolle H, Cortet C, Castinetti F, Cloix L, Caron P, Delemer B, Desailloud
R, Jublanc C, Lebrun-Frenay C, Sadoul JL, Taillandier L, Batisse-Lignier M,
Bonnet F, Bourcigaux N, Bresson D, Chabre O, Chanson P, Garcia C, Haissaguerre
M, Reznik Y, Borot S, Villa C, Vasiljevic A, Gaillard S, Jouanneau E, Assié G,
Raverot G. Temozolomide treatment can improve overall survival in aggressive
pituitary tumors and pituitary carcinomas. Eur J Endocrinol. 2017
Jun;176(6):769-777. doi: 10.1530/EJE-16-0979. PMID: 28432119.
33: Ferriere A, Cortet C, Chanson P, Delemer B, Caron P, Chabre O, Reznik Y,
Bertherat J, Rohmer V, Briet C, Raingeard I, Castinetti F, Beckers A, Vroonen L,
Maiter D, Cephise-Velayoudom FL, Nunes ML, Haissaguerre M, Tabarin A.
Cabergoline for Cushing’s disease: a large retrospective multicenter study. Eur
J Endocrinol. 2017 Mar;176(3):305-314. doi: 10.1530/EJE-16-0662. Epub 2016 Dec
- PMID: 28007845.
34: Giustina A, Bevan JS, Bronstein MD, Casanueva FF, Chanson P, Petersenn S,
Thanh XM, Sert C, Houchard A, Guillemin I, Melmed S; SAGIT Investigator Group.
SAGIT®: clinician-reported outcome instrument for managing acromegaly in
clinical practice–development and results from a pilot study. Pituitary. 2016
Feb;19(1):39-49. doi: 10.1007/s11102-015-0681-2. PMID: 26377024; PMCID:
PMC4710645.
35: Schopohl J, Gu F, Rubens R, Van Gaal L, Bertherat J, Ligueros-Saylan M,
Trovato A, Hughes G, Salgado LR, Boscaro M, Pivonello R; Pasireotide B2305 Study
Group. Pasireotide can induce sustained decreases in urinary cortisol and
provide clinical benefit in patients with Cushing’s disease: results from an
open-ended, open-label extension trial. Pituitary. 2015 Oct;18(5):604-12. doi:
10.1007/s11102-014-0618-1. PMID: 25537481; PMCID: PMC4560758.
36: Pivonello R, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M,
Trovato A, Hughes G, Salgado LR, Lacroix A, Schopohl J, Biller BM; Pasireotide
B2305 Study Group. Pasireotide treatment significantly improves clinical signs
and symptoms in patients with Cushing’s disease: results from a Phase III study.
Clin Endocrinol (Oxf). 2014 Sep;81(3):408-17. doi: 10.1111/cen.12431. Epub 2014
Mar 27. PMID: 24533697.
37: Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Sen K, Salgado
LR, Colao A, Biller BM; Pasireotide B2305 Study Group. High variability in
baseline urinary free cortisol values in patients with Cushing’s disease. Clin
Endocrinol (Oxf). 2014 Feb;80(2):261-9. doi: 10.1111/cen.12259.
38: Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M,
Schoenherr U, Mills D, Salgado LR, Biller BM; Pasireotide B2305 Study Group. A
12-month phase 3 study of pasireotide in Cushing’s disease. N Engl J Med. 2012
Mar 8;366(10):914-24. doi: 10.1056/NEJMoa1105743. Erratum in: N Engl J Med. 2012
Aug 23;367(8):780. PMID: 22397653.
39: Fieffe S, Morange I, Petrossians P, Chanson P, Rohmer V, Cortet C, Borson-
Chazot F, Brue T, Delemer B; French Acromegaly Registry. Diabetes in acromegaly,
prevalence, risk factors, and evolution: data from the French Acromegaly
Registry. Eur J Endocrinol. 2011 Jun;164(6):877-84.
40: Gatta B, Chabre O, Cortet C, Martinie M, Corcuff JB, Roger P, Tabarin A.
Reevaluation of the combined dexamethasone suppression-corticotropin-releasing
hormone test for differentiation of mild cushing’s disease from pseudo-Cushing’s
syndrome. J Clin Endocrinol Metab. 2007 Nov;92(11):4290-3.
41: Cortet B, Cortet C, Blanckaert F, d’Herbomez M, Marchandise X, Wémeau J-L,
Decoulx M, Dewailly D. Quantitative ultrasound of bone and markers of bone
turnover in Cushing’s syndrome. Osteoporos Int. 2001;12(2):117-23.
42: Chanson P, Boerlin V, Ajzenberg C, Bachelot Y, Benito P, Bringer J, Caron P,
Charbonnel B, Cortet C, Delemer B, Escobar-Jiménez F, Foubert L, Gaztambide S,
Jockenhoevel F, Kuhn JM, Leclere J, Lorcy Y, Perlemuter L, Prestele H, Roger P,
Rohmer V, Santen R, Sassolas G, Scherbaum WA, Schopohl J, Torres E, Varela C,
Villamil F, Webb SM. Comparison of octreotide acetate LAR and lanreotide SR in
patients with acromegaly. Clin Endocrinol (Oxf). 2000 Nov;53(5):577-86.
43: Waterlot C, Porchet N, Bauters C, Decoulx M, Wémeau JL, Proye C, Degand PM,
Aubert JP, Cortet C, Dewailly D. Type 1 multiple endocrine neoplasia (MEN1):
contribution of genetic analysis to the screening and follow-up of a large
French kindred. Clin Endocrinol (Oxf). 1999 Jul;51(1):101-7.
44 Jannin A, Merlen E, Do Cao C, Penel N. L’hypophysite auto-immune,
complication des nouvelles immunothérapies anticancéreuses [Autoimmune
hypophysitis associated with new anti-cancer immunotherapies]. Bull Cancer. 2018
Mar;105(3):275-280. French.
45 .Growth hormone replacement therapy in patients with traumatic brain injury. Moreau OK, Cortet-Rudelli C, Yollin E,Merlen E, Daveluy W, Rousseaux M.J Neurotrauma. 2013 Jun 1;30(11):998-1006. doi: 10.1089/neu.2012.2705. Epub 2013 Jun 5.PMID: 23323993
46 .asting pituitary hormone deficiency after traumatic brain injury.Kozlowski Moreau O, Yollin E,Merlen E, Daveluy W, Rousseaux M.J Neurotrauma. 2012 Jan 1;29(1):81-9.
47 . [Revelation of a polymicrocystic ovary syndrome after one month’s treatment by pulsatile GnRH in a patient presenting with functional hypothalamic amenorrhea].Reyss AC,Merlen E, Demerle C, Dewailly D.Gynecol Obstet Fertil. 2003 Dec;31(12):1039-42.